Possibly, but only through an employer that already qualifies as a treaty investor enterprise. The classification for employees requires that the enterprise be at least fifty percent owned by treaty-country nationals, that the employee share that nationality, and that the position be executive or supervisory, or require special qualifications essential to the enterprise.
Your eligibility is mostly a fact about your employer
This is an unusual situation in which the most important documents belong to someone else. Before spending time on a personal file, establish the ownership of the U.S. business: who the ultimate individual owners are, what citizenship they hold, whether any of them is a U.S. permanent resident, and whether the enterprise has been recognized as a treaty enterprise already. Owners are sometimes reluctant to share ownership records with a prospective employee, and that reluctance is itself information about how workable the plan is. Assuming the enterprise qualifies, the analysis moves to the position and to the applicant's own citizenship, which must match the treaty nationality of the qualifying owners. A licensed U.S. immigration attorney should assess both halves before anyone relies on this route.
Begin with an ownership chart and a transaction map. The review should establish the applicant's treaty nationality, the nationality of the enterprise, the actual capital commitment, and the person who will control day-to-day direction. Funds sitting free in an account do not establish an E-2 investment; they must be genuinely committed, exposed to commercial loss, and connected to a real enterprise that is not marginal. Hypothetical example: A specialty-coffee roaster is offered an investor role in a U.S. roasting company, but the subscription agreement lets her withdraw at will. The withdrawal right must be resolved before the amount is treated as qualifying capital.